Figure 2. Prioritized biological RA risk genes.
Representative biological RA risk genes. We list the summary gene score derived from individual criterion (filled red box indicates criterion satisfied; 98 genes with score ≥2 out of 377 genes included in the RA risk loci were defined as “biological candidate genes”; see details in Extended Data Fig. 6). Filled blue box indicates the nearest gene to the RA risk SNP. Filled green boxes indicate overlap with H3K4me3 peaks in immune-related cells. Filled purple boxes indicate overlap with drug target genes. Full results are in Supplementary Table 5.