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. Author manuscript; available in PMC: 2015 Mar 1.
Published in final edited form as: Allergy. 2013 Nov 25;69(3):315–327. doi: 10.1111/all.12321

Figure 1. Diphtheria Toxin (DT) mediated cell toxicity is limited to eosinophil progenitor cell populations with mature eosinophils unresponsive to DT exposure.

Figure 1

Ex vivo bone marrow cultures from iPHIL and wild type mice were exposed to DT (5ng/mL) during select culture time periods to assess for the differential ablation of eosinophil progenitors vs. terminally differentiated metamyelocytes. In the left panel (DT Administration – Eosinophil Differentiation), DT exposure was performed from protocol days 4–14 during the time of eosinophil progenitor expansion. In the right panel (DT Administration – Post-Eosinophil Differentiation), DT exposure was performed from protocol days 14–23 during the time when the cultures were >95% terminally differentiated metamyelocytes (Mature Eos).