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. 2014 Jan 21;10:224–236. doi: 10.3762/bjoc.10.18

Table 3.

Influence of phenyl substituents on yieldsa and selectivity (catalysts 7af, cf. Scheme 1).

catalyst R % yielda,b % eec

7a Ph 98 51 (R)
7b 3,5-(CF3)2-Ph 95 42 (R)
7c 3,5-Cl2-Ph 86 34 (R)
7d 3,5-F2 82 38 (R)
7e 4-NO2-Ph 69 43 (R)
7f 4-OMe-Ph 98 37 (R)

aAll reactions carried out in benzene, 10 mol % cat., rt, 1 h. bIsolated yields. cChiral HPLC Daicel OJ, hexane/iPrOH 50:50, 1.0 mL/min, 254 nm, (S)-enantiomer: 12.3 min (R)-enantiomer: 26.0 min.