Figure 3.

According to the International Society of Heart and Lung Transplantation (ISHLT) system for rejection grading, pathological sections of allograft rejection were shown. (A) grade 0, there is no lymphocytes inflammation and myocyte necrosis in allografts; (B) grade 1, there were no obvious inflammation and medium limited inflammatory infiltration and oedema in myocardial cell; (C) grade 2, there were local lymphocytic infiltration and faint myocardial cell necrosis in vascular and myocardial cell; (D) grade 3, it became moderate lymphocytic infiltration and faint myocardial cell necrosis; (E) grade 4, cardiomyocytes necrosis and multifocal aggressive interstitial lymphocytic infiltration in allografts; (F) Number of rats with different rejection grades in the pathological biopsy. [Original magnification (A,B,D,E) ×10, (C) ×40].