Table 1.
Clinical characteristics and fraction with HR mutations.
| All Subjects N | Fraction with Germline HR mutationa | Fraction with Somatic HR mutationa | |
|---|---|---|---|
|
| |||
| Median age (years) | 59 y | 53 y | 59 y |
| Range | (27–89 y) | (34–75 y) | (29–80 y) |
|
| |||
| Site | |||
| Ovary | 304 | .22 | .08 |
| Fallopian tube | 24 | .42 | .04 |
| Peritoneal | 32 | .22 | .03 |
| Synch Ov/Endo | 7 | .29 | .14 |
|
| |||
| Histology | |||
| High-gradeb serous | 249 | .26 | .05 |
| Low-gradec serous | 9 | .11 | 0 |
| Poorly-differentiated NOS | 48 | .25 | .13 |
| Clear cell | 19 | .05 | .21 |
| High-gradeb endometrioid | 20 | .15 | .10 |
| Low-gradec endometrioid | 6 | .17 | .17 |
| Carcinosarcoma | 12 | .25 | .08 |
| Otherd | 4 | .25 | 0 |
|
| |||
| Stagee | |||
| I | 36 | .17 | .14 |
| II | 19 | .16 | 0 |
| III | 255 | .24 | .08 |
| IV | 49 | .27 | .04 |
|
| |||
| Cytoreductione | |||
| Optimal | 243 | .23 | .09 |
| Suboptimal | 109 | .22 | .06 |
|
| |||
| Total | 367 | .24 | .08 |
a
Cases with both a germline and somatic HR mutation were included in the germline HR category
b
Grade 2–3
c
Grade 1
d
Other = one malignant Brenner’s, one mucinous, and two mixed carcinomas
e
stage was unknown for 8 cases
f
cytoreduction status was not available for 15 cases
Synch Ov/Endo: cases classified pathologically as having two primary cancers arising from the ovary and endometrium
NOS: not otherwise specified