Table 4.
ROC curve analyses for combinations of markers and the DR for preeclampsia at a fixed FPR of 10% and 5% using a logistic regression model
| Variable | Cutoff 1 | DR 1 | Cutoff 2 | DR 2 | Area | S E | p-value | 95% CI | Variable |
|---|---|---|---|---|---|---|---|---|---|
| PAPP-A + Inhibin A |
5.01% |
50 |
9.19% |
37.5 |
0.812 |
0.093 |
0.003 |
0.629 |
0.995 |
| PAPP-A + sFlt-1/PlGF1 |
2.85% |
87.5 |
4.72% |
87.5 |
0.969 |
0.015 |
<0.001 |
0.940 |
0.999 |
| PAPP-A + sFlt-1/PlGF2 |
2.62% |
62.5 |
4.07% |
50 |
0.917 |
0.036 |
<0.001 |
0.847 |
0.988 |
| BMI + sFlt-11 |
4.6% |
87.5 |
8.9% |
75 |
0.937 |
0.039 |
<0.001 |
0.861 |
1.000 |
| sFlt-1/PlGF1 + sFlt-1/PlGF2 | 2.2% | 87.5 | 3.4% | 87.5 | 0,946 | 0.043 | <0.001 | 0.862 | 1.000 |
The exploratory variable in each case is the risk determined by the logistic equation.
Cutoff1: cutoff value at a fixed FPR of 10%, DR1: DR at a fixed FPR of 10%, Cutoff2: cutoff value at a fixed FPR of 5%, DR2: DR at a fixed FPR of 5%, PAPP-A: pregnancy-associated plasma protein-A, sFlt-11: second trimester sFlt-1, sFlt-1/PlGF1: second trimester sFlt-1/PlGF ratio, sFlt-1/PlGF2: third trimester sFlt-1/PlGF ratio, SE: standard error.