Figure 1.

SIRT3 structure with its activators and inhibitors. SIRT3 is a soluble protein located in the mitochondrial matrix, containing a mitochondrial processing peptide at the N-terminus, with a conserved enzymatic core with two domains. Moreover, several SIRT3 activators (resveratrol and oroxylin A) and novel SIRT3 inhibitor 5-amino-2-phenyl-benzoxazole have also been reported