Table 2a. Top 10 genes downregulated in GBM8401 cells following exposure to CuE (5 μM).
| Gene name | Fold change | Genbank | Description |
|---|---|---|---|
| FLJ41423 | −5.310 | AK123417 | Homo sapiens cDNA FLJ41423 fis |
| C21orf135 | −4.991 | BE875542 | Homo sapiens cDNA clone IMAGE:3891427 5' |
| A_33_P3381132 | −4.955 | A_33_P3381132 | Unknown |
| CCL14 | −4.930 | NM_032963 | Homo sapiens chemokine (C-C motif) ligand 14 (CCL14) |
| LOC392435 | −4.789 | XM_001720500 | Homo sapiens similar to hCG1811022 (LOC392435) |
| CTLA4 | −4.762 | NM_005214 | Homo sapiens cytotoxic T-lymphocyte-associated protein 4 (CTLA4) |
| ADAMTS4 | −4.675 | NM_005099 | Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif, 4 |
| CNGA1 | −4.567 | NM_000087 | Homo sapiens cyclic nucleotide gated channel alpha 1 (CNGA1) |
| AX747659 | −4.534 | AX747659 | Sequence 1184 from Patent EP1308459. |
| CLCA1 | −4.500 | NM_001285 | Homo sapiens chloride channel accessory 1 (CLCA1) |
Abbreviations: CuE, cucurbitacin E; CCL14, C–C motif ligand protein; CLCA1, chloride channel accessory 1; CNGA1, cyclic nucleotide gated channel alpha 1; CTLA4, cytotoxic T-lymphocyte-associated protein 4; GBM, human brain malignant glioma.
Downregulated genes (n=558).