Table 1. ABT-737 IC50 following siRNA knockdown of target genes.
|
(a) ABT-737 IC50 (nM) | |||||||
|---|---|---|---|---|---|---|---|
| PSMD14 | PRPF8 | UBL5 | UCHL3 | USP17 | MCL1 | Sham | |
| Bcl2-dependent | |||||||
| SMS-SAN | 10 | 10 | 10 | 9 | 14 | 6 | 12 |
| Mcl1-dependent | |||||||
| IMR5 | 710 | 57 | 66 | 146 | >10 000 | 2 | 6802 |
| NLF | 572 | 2745 | 7701 | 1022 | >10 000 | 30 | >10 000 |
| Resistant | |||||||
| BE2C | 599 | >10 000 | >10 000 | 550 | >10 000 | 14 | >10 000 |
| SK-N-AS | >10 000 | >10 000 | >10 000 | 9136 | >10 000 | 41 | >10 000 |
|
(b) ABT-737 IC50 (nM) | |||||||
|---|---|---|---|---|---|---|---|
| siRNA no.1 | siRNA no.2 | siRNA no.3 | siRNA no.4 | ||||
| PSMD14 | |||||||
| IMR5 | 755 | 749 | 2609 | 6096 | |||
| NLF | 33 | 129 | 322 | 281 | |||
| PRPF8 | |||||||
| IMR5 | 167 | 129 | 7936 | 97 | |||
| NLF | 339 | 499 | >10 000 | 171 | |||
| UBL5 | |||||||
| IMR5 | >10 000 | 128 | 467 | 1137 | |||
| NLF | >10 000 | 2236 | 5149 | 9731 | |||
| UCHL3 | |||||||
| IMR5 | >10 000 | 2996 | 235 | >10 000 | |||
| NLF | >10 000 | 9684 | 652 | 9308 | |||
Underlined text, 5–10-fold decrease in IC50 from sham control knockdown; bold and underlined text, >10-fold decrease