Figure 2.

Echocardiographic phenotyping of DJ-1 WT and KO animals. (a–d) Isoproterenol (4 ng/g) treatment significantly increased the heart rate and fractional shortening in both DJ-1 WT and KO mice (n≥5/group; significance assessed by one-way ANOVA comparing WT Basal with WT ISO and KO Basal with KO ISO, where **P<0.01 and ***P<0.001). There were no significant differences in any cardiac parameter between DJ-1 WT and KO mice at baseline or in response to isoproterenol challenge (n≥5/group, significance assessed by one-way ANOVA comparing WT and KO, ^NSP>0.05)