Table 1. Characterization of cellular models.
Cell line | Origin | HPV status | HER1 (EGFR) expression | HER2 expression | HER3 expression | HER4 expression | Cetuximab sensitivity | Tumor-forming capacitiy in vivo |
---|---|---|---|---|---|---|---|---|
FaDu | HNSCC | − | ++ | + | + | − | ++ | + |
UD-SCC-17B | HNSCC | − | ++ | + | + | − | − | − |
UPCI:SCC-090 | HNSCC | + | + | + | + | − | ++ | + |
DU-SCC-2 | HNSCC | + | + | (+) | − | − | − | − |
DIFI | CRC | − | ++ | + | + | − | +++ | + |
A431 | Epidermoid cell carcinoma | − | +++ | + | (+) | − | + | + |
−: negative; (+): weak positive; +: positive; ++: strong positive; +++: highest intensity