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. 2014 Jan 7;22(3):547–553. doi: 10.1038/mt.2013.267

Figure 3.

Figure 3

Potential interactions of K16ApoE and tripeptidyl peptidase I (TPP1). (a) Dynamic light scattering. Particle diameters are measured for TPP1 (80 µl) and K16ApoE alone, or mixed in ratios of 1:1 or 1:5 respectively. (b) TPP1 (8 nmol in 100 µl) was administered to 6-week-old late-infantile neuronal ceroid lipofuscinosis (LINCL) mice at the indicated times after K16ApoE (14 nmol in 100 µl) (open circles). A TPP1 alone control (no peptide) is also shown (filled squares). Animals were killed 24 hours after injection and TPP1 activity was assayed in brain.