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. 2014 Jan 7;22(3):547–553. doi: 10.1038/mt.2013.267

Figure 4.

Figure 4

Effect of K16ApoE-mediated tripeptidyl peptidase I (TPP1) delivery on SCMAS storage in brain. Starting at 13 weeks of age, late-infantile neuronal ceroid lipofuscinosis (LINCL) mice were administered three weekly doses of K16ApoE (48 nmol) and TPP1 (17 nmol) in a total volume of 120 µl using a 3.75-minute infusion time. Treated mice were killed at 16 weeks of age and analyzed in parallel with untreated 13- and 16-week-old wild-type and LINCL mice. SCMAS storage is significantly different among the three groups of LINCL mice (P < 0.05 for each pairwise comparison using the Newman–Keuls multiple comparison test).