Figure 6.

Effect of K16ApoE on ERT in late-infantile neuronal ceroid lipofuscinosis (LINCL) mice. Gait analysis. Graphs represent stride length for (a) fore- and (b) rear-limbs. The tripeptidyl peptidase I (TPP1)+K16ApoE treated group was indistinguishable from wild-type (P > 0.05) but significantly different from the untreated group or group treated with TPP1 alone at 105 and 119 days (P < 0.001 using one-way analysis of variance for each timepoint with the Newman–Keuls multiple comparison test). Error bars indicate standard error of the mean of 3–10 animals per group. (c) Survival analysis.