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. Author manuscript; available in PMC: 2015 Mar 1.
Published in final edited form as: Anesthesiology. 2014 Mar;120(3):714–723. doi: 10.1097/ALN.0000000000000076

Figure 6.

Figure 6

A) Dezocine (magenta) sits in the preformed ligand binding pocket for selective serotonin reuptake inhibitors in the model of human serotonin transporter. The key interacting residues lining the pocket (Y95, D98, I172, Y176, F335, F341, and S438) are colored in yellow. This binding pocket has been demonstrated to be the binding site for many important clinical drugs such as fluoxetine, sertraline, and amitriptyline. B) Dezocine (magenta) shares the same binding pocket and overlap well with desiprimine (orange), the ligand in the LeuT crystal structure (2QJU).