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. 2013 Aug 5;5(8):1213–1226. doi: 10.1002/emmm.201201929

Figure 1.

Figure 1

IgA EGFR mediates efficient tumour cell killing ex vivo.
  1. Specific lysis of A1207 cells by isolated human PMNs (E:T = 80:1) in the presence of EGFR antibodies in a 4 h 51Cr-release assay.
  2. Specific lysis of A1207 cells using human PBMC (E:T = 100:1), monocyte-depleted PBMC fraction (E:T = 100:1) or isolated CD14+ monocytes (E:T = 25:1) in a 20 h 51Cr-release assay using 1 μg/mL EGFR antibodies.
  3. Specific lysis of human A1207 cells in vitro by G-CSF-primed whole mouse blood using wild-type C57BL/6 (C) or FcαRI Tg (D) mice in a 4 h 51Cr-release assay.
  4. Specific lysis of A1207 cells at different E:T ratios with 10 μg/mL EGFR antibody using G-CSF-primed whole blood from FcαRI Tg mice. Data are presented as mean percentage of specific lysis ± SEM from one representative experiment out of three using pooled mouse blood.