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. 2013 Aug 5;5(8):1213–1226. doi: 10.1002/emmm.201201929

Figure 2.

Figure 2

Serum half-life of human IgA EGFR in SCID mice
  1. SCID mice were injected intraperitoneally with 100 μg of IgA1 EGFR, IgA2 EGFR or cetuximab. Blood was drawn at the indicated time points and the concentration of circulating antibodies was determined by ELISA. The first time point represents 1 h.
  2. Serum levels of circulating IgA1 EGFR after intraperitoneal or intravenous injection of antibodies. The first time point represents 5 min.
  3. Blocking asialoglycoprotein receptor (ASGP-R) by the injection of 3 mg asialofetuin on Day 0 temporarily inhibited the clearance of i.v. injected 200 μg IgA1 and IgA2 EGFR in vivo in BALB/c mice (***p < 0.001 Students' t-test).