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. 2013 Jul 8;5(8):1227–1246. doi: 10.1002/emmm.201202258

Figure 6.

Figure 6

PrPC knockout impaired recruitment of bone marrow derived cell (BMDC) and exacerbated stroke damage in vivo
  1. Wild type (Prnp+/+) and PrPC-knockout (Prnp0/0) chimeric mice expressing GFP+ BMDCs were subjected to cerebral ischemia. GFP+ BMDCs were found in great abundance in the brains from Prnp+/+ mice, but not in brains from Prnp0/0 mice, 3 day post-cerebral ischemia.
  2. Volume of cerebral infarction in wild type (Prnp+/+) and PrPC-knockout (Prnp0/0) chimeric mice, measured by MRI at 3 day, 7 day and 28 day post-cerebral ischemia.
  3. 3D immunofluorescent images showing co-expression of PrPC in CD34+GFP+ BMDCs in the penumbric area of the brain. Scale bar, 50 µm.