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. 2014 Jan 30;7(3):351–362. doi: 10.1242/dmm.014050

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© 2014. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 4. — Increased rate of cell death and oxidative stress in Ncu-g1^gt/gt liver. (A) Liver sections labeled for active caspase 3 and counterstained with Mayer’s hematoxylin indicate apoptosis (long arrows) and inflammation (short arrows) in Ncu-g1^gt/gt mice. Scale bar: 50 μm. (B) Representative western blot showing caspase 3 expression in wild-type (WT) and Ncu-g1^gt/gt liver. The levels of active caspase 3 were significantly higher in Ncu-g1^gt/gt liver homogenates (n=4, *P<0.05). (C) Expression of genes involved in oxidative stress (iNos2, Gpx3, Sod3, Noxa1) were elevated in Ncu-g1^gt/gt liver (n=4, *P<0.05, **P<0.005). Values are expressed as mean±s.e.m.