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. 2014 Jan 30;7(3):373–385. doi: 10.1242/dmm.012104

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© 2014. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 4. — Expression of human APP and BACE in Drosophila alters synapse formation. (A,B) Confocal image of the synapse of segment A3, muscle 6/7 stained with neuronal marker, HRP. (A) elav; +; + heterozygous larvae. (B) elav; APP; BACE (low) heterozygous larvae. Scale bar: 10 μm. Arrows represent 1s type boutons; arrowheads represent 1b type boutons. (C–G) Histograms depict quantitative analysis of bouton and branch number on muscles 6 and 7 at abdominal segment 3. (C) Total number of boutons. (D) Number of 1s type boutons. (E) Number of 1b type boutons. (F) Total number of branches. (G) Average muscle 6 and 7 area. Treatments are indicated. Analysis represents n>15. *P<0.05. Error bar represents standard error in each case.