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. 2014 Jan 27;12(2):700–718. doi: 10.3390/md12020700

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© 2014 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Blockage of FCCP inhibition on cytoplasmic calcium entrance induced after endoplasmic reticulum emptying by Thapsigargin (Tg) produced by Spongionella compounds. (a) Bars histogram represents maximal Ca²⁺ entry observed after the ion restoration. The potency of these compounds to block the effect of FCCP calcium entrance induced by Tg is C > E > F > D; (b) Compound C effect over Ca²⁺ release from endoplasmatic reticulum induced by thapsigargin. * Significant differences between FCCP and compounds C, D, E and F pre-treated cells.