Table 1.

In vivo effect of fucoidan on tumor growth in tumor-bearing mice.

Fucoidan	Route/Dose	Tumor Type	Action Mechanism	References
Cladosiphon okamuranus	p.o. 5 g/kg	26 colon cancer cells	Natural killer (NK) cell-mediated	[11]
Fucus vesiculosus (Sigma, St. Louis, MO, USA)	i.p. 5 mg/kg	4T1 breast cancer cells	Inhibition of angiogenesis and induction of apoptosis	[24,25]
Fucus evanescence	10 mg/kg	Lewis lung carcinoma cells	Unknown	[27]
From Ze Lang Nanjing Med. Tech Co.	i.p. 200 mg/kg	Bel-7402 hepatocellular carcinoma in nude mice	Inhibition of proliferation	[28]
Fucus vesiculosus (Sigma, St. Louis, MO, USA)	Foot-pad injection 0.25 mg/mice	4T1-xenograft mice	Prevention of metastasis	[29]
Sargassum plagiophyllum	p.o. 75 mg/kg	Diethylnitrosamine-induced hepatocellular carcinoma	Inhibition of carcinogen metabolism	[30]
Cladosiphon okamuranus Tokida	p.o. 100 mg/kg	Sarcoma 180 (S-180)-xenograft	Delayed tumor growth by nitric oxide produced by macrophages	[31]
Undaria pinnatifida	Diet containing 1% Mekabu (34 mg/day)	A20 leukemia cells	Cytolytic activity by NK cell activation	[32]
Fucus vesiculosus (Sigma, St. Louis, MO, USA)	i.v. 5 mg/kg	Lewis lung carcinoma cells B16 melanoma cells	Antiangiogenic effect	[33]
Ascophyllum nodosum	1 mg/mice	MOPC-315 plasma cell tumor	Prevention of angiogenesis in tumor tissues	[34]