Scheme 2.
Synthesis of 4-phenyl-2-aminoimidazoles 5a–k and 6a–k and 4-phenyl-2-(N-methylamino)-imidazoles 5l and 6l. Reagents and conditions: (a) Corresponding carboxylic acid, TBTU, NMM, CH2Cl2, 35 °C, 24 h; (b) HCl(g), THF/EtOH, rt, 5 h.
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