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. 2014 Feb 18;106(4):875–882. doi: 10.1016/j.bpj.2014.01.005

Figure 4.

Figure 4

The ω angle between entry/exit sites of DNA is 8° smaller in CENP-A than in H3 arrays. (A and C) ω Angle histogram of CENP-A with open (A) and crossed DNA entry/exit site (C). (B and D) As in A and C, but for canonical H3 trinucleosomes. The mean ω angle and its SD are indicated above the histogram peaks. The mean ω angles are 74° (SD = 32°) and 77° (SD = 32°) for canonical H3, and 68° (SD = 25°) and 66° (SD = 27°) for CENP-A nucleosomes with crossed/open DNA entry/exit site. The values for the ω angles of crossed and open DNA entry/exit sites of CENP-A and canonical H3 data sets differ significantly from each other according to an unpaired two-sample t-test (p-value < 0.05). The sample size is 175 for CENP-A (open: 96; crossed: 79) and 176 trinucleosomes for canonical H3 (open: 60; crossed: 116). In each panel the curve fitting is superimposed on its corresponding color.