Table 2. Distribution of genetic polymorphisms in the groups of healthy individuals and people with schizophrenia, and calculation of oligogenic scores.
| Group | COMT rs4680 |
DRD2 rs2283265 genotype |
Row total | ||
|---|---|---|---|---|---|
| GG | GT | TT | |||
| People with schizophrenia | Met/Met | 6 (OS=0) | 1 (OS=1) | 0 (OS=2) | 7 |
| Val/Met | 12 (OS=1) | 4 (OS=2) | 0 (OS=3) | 16 | |
| Val/Val | 3 (OS=2) | 1 (OS=3) | 0 (OS=4) | 4 | |
| Column total | 21 | 6 | 0 | 27 | |
| Healthy individuals | Met/Met | 6 (OS=0) | 5 (OS=1) | 0 (OS=2) | 11 |
| Val/Met | 17 (OS=1) | 3 (OS=2) | 1 (OS=3) | 21 | |
| Val/Val | 9 (OS=2) | 2 (OS=3) | 0 (OS=4) | 11 | |
| Column total | 32 | 10 | 1 | 43 | |
| Group |
Oligogenic score |
||||
| |
0 |
1 |
2 |
3 |
4 |
| People with schizophrenia | 6 | 13 | 7 | 1 | 0 |
| Healthy individuals | 6 | 22 | 12 | 3 | 0 |
| Column total | 12 | 35 | 19 | 4 | 0 |
Abbreviations: COMT, catechol-O-methyltransferase; DRD2, dopamine D2 receptor; OS, oligogenic score. Numbers represent the numbers of participants in each category.