Figure 2.

Maternal immune activation (MIA) induces cognitive deficits but does not alter general behavioral function. Cognitive evaluation of adult PIC mice using the Morris water maze (MWM) task. (a) Latencies in the acquisition phase of MWM of PIC (red) relative to controls (blue). (b) Sample tracking pathways during the last training day (TD3). Target platform in top left quadrant. (c) Percentage of time spent in the target quadrant during the first 15 s of the probe trial. (d) Locomotor activity evaluated by the total distance traveled in the open field. (e) Motor coordination evaluation using the rota rod. n=10–34 per group. Data represent mean±s.e.m. *P<0.05, **P<0.01, n.s. not significant.