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. 2013 Oct 9;85(3):570–578. doi: 10.1038/ki.2013.398

Figure 4.

Figure 4

Effect of N-acethylcysteine (NAC) infusion on renal ischemia/reperfusion (IR) injury. Effect of an antioxidant, NAC, on (a) dimethylarginine dimethylaminohydrolase (DDAH) enzymatic activity, (b) renal, and (c) plasma levels of asymmetric dimethylarginine (ADMA) and (d, e) renal function. Wild mice (n=22) were subjected to 45 min of bilateral renal ischemia. Then, reperfusion was allowed by means of clips removal for 24 h. NAC (300 mg/kg of body weight) was administered intraperioneally at 1 day and 15 min before IR injury (n=6). Sham-operated mice (n=18) were used as a control. BUN, blood urea nitrogen; Cr, creatinine.