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. 2013 Oct 9;85(3):570–578. doi: 10.1038/ki.2013.398

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Copyright © 2013 International Society of Nephrology

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/

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Mechanism of renal dimethylarginine dimethylaminohydrolase (DDAH)-1 alteration in ischemia/reperfusion (IR) injury. Effects of a proteasomal inhibitor MG-132 on (a) dimethylarginine dimethylaminohydrolase (DDAH)-1 levels, (b) plasma asymmetric dimethylarginine (ADMA) levels, and (c, d) renal function. Wild mice (n=11) were subjected to 45 min of bilateral renal ischemia. Then, reperfusion was allowed by means of clips removal for 24 h. Mice were treated with MG-132 (n=5) or dimethyl sulfoxide (n=6) before IR. Sham-operated mice were used as a control (n=18). (a) Upper panel shows the representative bands of western blots. Lower panel shows the quantitative data. Data were normalized by the intensity of β-actin and related to the value of the control. The results of densitometric analysis are presented as a fold change compared with control mice. a.u., arbitrary units; BUN, blood urea nitrogen; Cr, creatinine.