Figure 1.

Effect of β-lapachone (βL) on serum creatinine and blood urea nitrogen (BUN) in cisplatin-induced acute kidney injury. βL (40 mg/kg body weight) was administered orally once a day for 4 consecutive days. Cisplatin (20 mg/kg body weight) was injected once at 12 h after the first βL administration. The mice were killed at 72 h after the single cisplatin injection, and levels of (a) serum creatinine and (b) BUN were analyzed using an assay kit according to the manufacturer's instructions (BioVision). To observe the effect of βL on the cisplatin-induced toxicity with the experimental time course, the mice were killed daily after cisplatin injection, and serum was analyzed for (c) creatinine and (d) BUN. ^*,#P<0.05 by one-way analysis of variance compared with the control (*) and cisplatin+βL group (#) (n=5).