Table 3.
Estimates of FFS among all patients and by histologic subtype and delivery of RT
| Week 12 Response | n (%) | 5 year FFS (95% CI) | p-value1 |
|---|---|---|---|
| All Patients | (N=338) | ||
| CR | 95 (28) | 74% (64%, 82%) | 0.49 |
| PR | 193 (57) | 75% (63%, 83%) | |
| NR | 50 (15) | 64% (47%, 82%) | |
| Week 12 or later RT | (N=237) | ||
| CR | 76 (32) | 75% (63%, 83%) | 0.66 |
| PR | 132 (56) | 76% (68%, 83%) | |
| NR | 29 (12) | 68% (47%, 82%) | |
| Embryonal histology | (N=165) | ||
| CR | 43 (26) | 86% (72%, 93%) | 0.89 |
| PR | 98 (59) | 80% (71%, 87%) | |
| NR | 24 (15) | 78% (55%, 90%) | |
| Alveolar histology | (N=72) | ||
| CR | 33 (46) | 59% (40%, 74%) | 0.08 |
| PR | 34 (47) | 63% (44%, 77%) | |
| NR | 5 (7) | 20% (0.8%, 58%)1 | |
| Parameningeal primary with ICE, early RT | (N=65) | ||
| CR | 5 (7) | 100% (--) | 0.44 |
| PR | 43 (66) | 74% (58%, 85%) | |
| NR | 17 (26) | 68% (38%, 86%) | |
| No RT | (N=36) | ||
| CR | 14 (39) | 63% (33%, 83%) | 0.39 |
| PR | 18 (50) | 67% (40%, 83%) | |
| NR | 4 (11) | 25% (0.9%, 67%)2 | |
1
Based on log-rank test
Abbreviations: failure-free survival, FFS; complete response, CR; partial response, PR; no response, NR; radiation therapy, RT; intracranial extension, ICE