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. 2014 Mar 6;4:4292. doi: 10.1038/srep04292

Figure 2. Phylogenetic tree of family S46 peptidases.

Figure 2

The phylogenetic tree with DAP BII, PgDPP7, PgDPP11, and SpDPP11 was derived on the basis of a sequence set containing 81 peptidase sequences from 48 independent phylogenetic families by MUSCLE multiple sequence alignment and maximum likelihood analysis. The figure was generated using the MEGA program; enclosed clusters are phyla of source organisms and colored circles indicate known family S46 peptidases that differ with respect to the residue that is predicted to recognize the P1 residue of the substrate: glycine (magenta), arginine (blue), or serine (green). In DAP BII, the putative P1-interactive residue is glycine (red).