Table 1.
Baseline characteristics of patients from the sepsis cohort
|
Characteristic |
N |
Cases |
Controls |
Combined |
P
-value |
|---|---|---|---|---|---|
| (n = 120) | (n = 120) | (n = 240) | |||
| Agec (IQR) |
240 |
59.3 (53.2, 65.7) |
59.3 (52.7, 65.7) |
59.3 (53.2, 65.7) |
0.885a |
| Female gender (%) |
240 |
53 (44) |
56 (47) |
109 (45) |
0.791b |
| Smoking (%) |
231 |
|
|
|
0.505b |
| Never |
|
40 (34) |
33 (29) |
73 (32) |
|
| Former |
|
44 (38) |
40 (35) |
84 (36) |
|
| Current |
|
33 (28) |
41 (36) |
74 (32) |
|
| Diabetes (%) |
240 |
31 (26) |
47 (39) |
78 (32) |
0.045b |
| Summer season (%) |
240 |
34 (28) |
35 (29) |
69 (29) |
1b |
| Day length hours (IQR)c |
240 |
12.0 (10.6, 13.6) |
12.0 (10.6, 13.5) |
12.0 (10.6, 13.6) |
0.655a |
| APACHE II Score (IQR)c |
240 |
28 (23, 32.2) |
28 (23, 32.2) |
28 (23, 32.2) |
NA |
| Number of non-pulmonary organ failures (%) |
240 |
|
|
|
0.753a |
| 0 |
|
15 (12) |
24 (20) |
39 (16) |
|
| 1 |
|
60 (50) |
45 (38) |
105 (44) |
|
| 2 |
|
39 (32) |
39 (32) |
78 (32) |
|
| 3 |
|
4 (3) |
9 (8) |
13 (5) |
|
| 4 |
|
2 (2) |
3 (2) |
5 (2) |
|
| Days of ICU stay (IQR) |
240 |
9 (6,15) |
6 (4,10) |
7 (4,14) |
0.008a |
| Hospital mortality (%) |
240 |
30 (25) |
31 (26) |
61 (25) |
1b |
| One-year mortality (%) |
240 |
66 (55) |
71 (59) |
137 (57) |
0.614b |
| Risk factors for ALI/ARDS |
240 |
|
|
|
< 0.001b |
| Non-pulmonary sepsis |
|
55 (46) |
70 (60) |
125 (53) |
|
| Pneumonia |
|
39 (33) |
22 (19) |
61 (26) |
|
| Aspiration |
|
24 (20) |
8 (7) |
32 (14) |
|
| Other or Noned |
|
1 (1) |
16 (14) |
17 (16) |
|
| Patients on ventilator |
|
89 (74) |
71 (59) |
160 (67) |
0.016b |
| 25-OHD (nmol/L) (IQR) |
239 |
45.8 (29.9, 60.8) |
39.0 (25.0, 56.9) |
43.2 (27.6, 58.8) |
0.123a |
| Vitamin D status (%) |
239 |
|
|
|
0.358b |
| Deficiency (< 50 nmol/L) |
|
72 (60) |
82 (69) |
154 (64) |
|
| Insufficiency (50 to 75 nmol/L) |
|
32 (27) |
26 (22) |
58 (24) |
|
| Sufficiency (> 75 nmol/L) | 16 (13) | 11 (9) | 27 (11) |
Data given as median with interquartile range (IQR) or frequency with (%) of patients.
N is the number of non-missing values.
aWilcoxon signed rank test; bMcNemar’s test; cMatched; dOther or None (pancreatitis, multiple transfusions, trauma).