Table 1.

MAC Cohort Protocol for Eligibility of UVA1 Phototherapy^*

1. Diagnosis of Morphea :

- linear, plaque, generalized, or mixed16

2. Presence of at least one active morphea lesion. Active morphea is defined as follows:

Active disease criteria

Presence of one of these features qualifies as active disease:

1. New lesion developed within preceding 3 months, documented by clinician

2. Extension of existing lesion within prior 3 months, documented by clinician

3. Erythema of moderate or marked level in lesion or an erythematous lesion border, + documented by clinician

4. Violaceous lesion or border color, documented by clinician

Presence of 2 or more of these features qualifies as active disease:

1. Patient or parent report of new lesion OR extension of existing lesion occurring within prior 3 months

a. This criteria ONLY allowed for new patients (i.e., first visit)

2. Lesion warmth

3. Mild erythema of lesion

4. Marked or moderate induration of lesion border

5. Worsening hair loss in scalp, eyebrow, or eyelashes; must be documented by clinician

6. Lesion biopsy showing active disease. Pathologist reading biopsy would specify if there was activity defined as presence of inflammatory cell infiltrate.

^*This is not a proposed therapeutic guideline. This is current practice in the MAC cohort protocol and derived from a previous study.20