Table 2.
Cox proportional hazard regression on risk of CHF in all patients with body weight measurement after 1 month (n=761)
| Risk Marker | Hazard Ratio (95% Confidence Interval) | P Value |
|---|---|---|
| Avosentan | 2.28 (1.15 to 4.51) | 0.02 |
| Age, yr | 1.03 (1.00 to 1.07) | 0.05 |
| Hemoglobin A1C, % | 0.83 (0.68 to 1.00) | 0.06 |
| eGFR, ml/min per 1.73 m2 | 0.98 (0.95 to 1.00) | 0.09 |
| ACR, mg/mmola | 1.39 (0.98 to 1.96) | 0.06 |
| History of cardiovascular disease | 1.97 (1.15 to 3.37) | 0.01 |
| Insulin use | 2.32 (1.17 to 4.59) | 0.02 |
| Weight change after month 1, kg | 0.80 (0.60 to 1.07) | 0.13 |
| Avosentan×weight change after month 1, kg | 1.38 (1.02 to 1.88) | 0.04 |
Backward stepwise regression containing all predictors that showed a relation with CHF in univariable analysis (P<0.10). ACR, albumin-to-creatinine ratio.
a
ACR values are log-normalized.