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. 2014 Feb 18;5(1):e01117-13. doi: 10.1128/mBio.01117-13

FIG 4 .

FIG 4 

Parasite load, survival, and systemic IL-18 levels in NLRP1-knockout mice following Toxoplasma challenge. (A) Bioluminescence imaging of 76K GFP-LUC-infected mice (various strains, 10,000 tachyzoites, i.p. route) on days 5 to 7 following infection is shown. Images shown are three representative mice from 4 to 6 mice/group from one representative experiment. The experiment shown is one of 2 WT or 2 NLRP1 independent experiments. (B) P values (t test) comparing luciferase activity for each knockout strain to C57BL/6NTac are <0.05. (C) Aggregate survival curve of NLRP1 (n = 10)-knockout mice compared with WT C57BL/6NTac control mice (n = 10). (D) IL-18 measurements in serum of deficient mice on day 5 after infection. No detectable levels of IL-1β were detected in circulation.