Table 3.

Associations of TMEM106B rs3173615 with age at onset for probands in cohort 1

	Association between rs3173615 and age at onset
Model	Regression coefficient (95% CI)	P-value
Recessive (GG vs. CC or CG)	−1.26 (−4.78, 2.25)	0.48
Additive (effect of each additional G allele)	−0.24 (−2.04, 1.55)	0.79
Dominant (CG or GG vs. CC)	0.16 (−2.30, 2.63)	0.90
Co-dominant
CG vs. CC	0.45 (−2.12, 3.02)	0.73
GG vs. CC	−0.99 (−4.84, 2.85)	0.61

Regression coefficients, 95% CIs, and p-values result from linear regression models adjusted for age and disease group. Regression coefficients are interpreted as the change in mean age at onset corresponding to presence of the GG genotype for rs3173615 (recessive model), to each additional G allele for rs3173615 (additive model), and to presence of the CG or GG genotype for rs3173615 (dominant model). For the co-dominant model, regression coefficients are interpreted as the change in mean age at onset in comparison to the CC genotype for rs3173615.