Table 4.
TDP-43 burden of patients with TDP-43 Type A pathology
Group | C9ORF72 expansion | Genotype | Age at Death | Gender | TDP-43 Count | |
---|---|---|---|---|---|---|
Cohort 1 | a | Yes | GG | 90 | F | 7.7 |
b | Yes | CC | 83 | F | 10.5 | |
c | Yes | CC | 74 | M | 11.0 | |
d | Yes | CC | 71 | M | 20.5 | |
Cohort 2 | e | No | GG | 90 | F | 4.5 |
f | No | CC | 84 | M | 6.0 | |
g | No | CC | 86 | M | 16.7 | |
h | No | CC | 77 | M | 24.2 |
Subjects are homozygous carriers of the minor TMEM106B allele (GG), or of the major TMEM106B allele (CC) in rs3173615. TDP-43 counts were performed in six 10× microscopic fields randomly selected over the gyrus, and averaged for a composite pathologic burden score. Identifiers correspond to Fig. 1.