Table 2. Baseline clinical characteristics for patients with drug-resistant TB, Thailand, 2004–2008*.
| Characteristic | No. (%) patients with |
Patients with RIF-resistant vs. MDR TB, p value‡ | ||||||
|---|---|---|---|---|---|---|---|---|
| RIF-resistant TB, n = 121 |
MDR TB, n = 369 |
|||||||
| Included, n = 36 | Excluded, n = 85 | P value† | Included, n = 172 | Excluded, n = 197 | P value† | |||
| Case status | ||||||||
| New | 26 (72.2) | 56 (65.9) | 0.64 | 89 (51.7) | 95 (48.2) | 0.51 | 0.17 | |
| Retreatment after relapse | 6 (16.7) | 19 (22.4) | 25 (14.5) | 24 (12.2) | ||||
| Retreatment after failure | 2 (5.6) | 1 (1.2) | 21 (12.2) | 19 (9.6) | ||||
| Retreatment after default | 1 (2.8) | 4 (4.7) | 14 (8.1) | 18 (9.1) | ||||
| Transfer in | 0 (0.0) | 1 (1.2) | 10 (5.8) | 16 (8.1) | ||||
| Other |
1 (2.8) |
4 (4.7) |
|
|
13 (7.6) |
25 (12.7) |
|
|
| Site of TB | ||||||||
| Pulmonary | 33 (91.7) | 61 (71.8) | 0.05 | 160 (93.0) | 162 (82.2) | 0.008 | 0.69 | |
| Extrapulmonary | 2 (5.6) | 13 (15.3) | 5 (2.9) | 15 (7.6) | ||||
| Both |
1 (2.8) |
11 (12.9) |
|
|
7 (4.1) |
20 (10.2) |
|
|
| Cough >2 wk | ||||||||
| No | 11 (30.6) | 39 (45.9) | 0.22 | 40 (23.3) | 61 (31.0) | <0.001 | 0.36 | |
| Yes | 25 (69.4) | 45 (52.9) | 132 (76.7) | 123 (62.4) | ||||
| Data missing |
0 (0.0) |
1 (1.2) |
|
|
0 (0.0) |
13 (6.6) |
|
|
| Smear status | ||||||||
| Negative | 4 (11.1) | 11 (12.9) | 0.44 | 26 (15.1) | 26 (13.2) | 0.57 | 0.71 | |
| Positive | 30 (83.3) | 63 (74.1) | 140 (81.4) | 160 (81.2) | ||||
| Data missing |
2 (5.6) |
11 (12.9) |
|
|
6 (3.5) |
11 (5.6) |
|
|
| Chest radiograph | ||||||||
| Normal | 0 (0.0) | 4 (4.7) | 0.27 | 4 (2.3) | 10 (5.1) | 0.17 | 0.79 | |
| Abnormal, no cavity | 22 (61.1) | 41 (48.2) | 109 (63.4) | 104 (52.8) | ||||
| Abnormal, with cavity | 8 (22.2) | 29 (34.1) | 34 (19.8) | 48 (24.4) | ||||
| Data missing |
6 (16.7) |
11 (12.9) |
|
|
25 (14.5) |
35 (17.8) |
|
|
| HIV status | ||||||||
| Negative | 23 (63.9) | 29 (34.1) | 0.004 | 112 (65.1) | 92 (46.7) | 0.001 | 0.17 | |
| Positive | 13 (36.1) | 46 (54.1) | 47 (27.3) | 75 (38.1) | ||||
| Data missing |
0 (0.0) |
10 (11.8) |
|
|
13 (7.6) |
30 (15.2) |
|
|
| Outcome | ||||||||
| Treatment success | ||||||||
| TB cured | 20 (55.6) | 26 (30.6) | 0.25 | 51 (29.7) | 33 (16.8) | 0.06 | 0.07 | |
| Treatment completed | 5 (13.9) | 21 (24.7) | 25 (14.5) | 36 (18.3) | ||||
| Poor outcome | ||||||||
| Treatment failed | 1 (2.8) | 5 (5.9) | 31 (18.0) | 29 (14.7) | ||||
| Patient defaulted | 3 (8.3) | 10 (11.8) | 17 (9.9) | 28 (14.2) | ||||
| Patient died | 5 (13.9) | 12 (14.1) | 30 (17.4) | 40 (20.3) | ||||
| Transferred out | 2 (5.6) | 9 (10.6) | 15 (8.7) | 23 (11.7) | ||||
| Ongoing treatment | 0 | 2 (2.4) | 3 (1.7) | 8 (4.1) | ||||
*Patients were from the Thailand TB Active Surveillance Network and were either included or not included in the current study. TB, tuberculosis; RIF, rifampin; MDR, multidrug-resistance. †p values reflect comparison between included and excluded patients in each TB drug resistance group. ‡p values reflect comparison between included RIF-resistant and MDR TB patients.