Table 4. Association between baseline sociodemographic and clinical characteristics and prescription of an inappropriate MDR TB treatment regimen for 172 MDR TB patients 2004–2008*.
| Characteristic | Univariate OR (95% CI) | p value | Multivariate OR (95% CI)† | p value |
|---|---|---|---|---|
| Age, y | ||||
| <45 | Reference | |||
| >45 | 0.54 (0.2–1.2) | 0.13 | ||
| Sex | ||||
| Male | Reference | |||
| Female | 0.74 (0.3–1.8) | 0.49 | ||
| Marital Status | ||||
| Married | Reference | |||
| Single/divorced/widowed | 0.44 (0.2–1.0) | 0.06 | ||
| Nationality | ||||
| Thai | Reference | |||
| Non-Thai | 1.0 (0.4–3.0) | 0.95 | ||
| Case status | ||||
| New | Reference | Reference | ||
| Retreatment | 2.4 (1.0–5.9) | 0.05 | 2.6 (1.0–6.3) | 0.04 |
| Transfer in/other | 2.8 (0.9–8.7) | 0.08 | 2.9 (0.9–9.3) | 0.07 |
| Site of TB | ||||
| Pulmonary | Reference | |||
| Extrapulmonary or both | 0.41 (0.1–3.3) | 0.40 | ||
| Cough >2 wk | ||||
| No | Reference | |||
| Yes | 1.6 (0.6–4.6) | 0.35 | ||
| Smear status | ||||
| Negative | Reference | |||
| Positive | 6.5 (0.8–50.2) | 0.07 | ||
| Cavitation seen on chest x-ray | ||||
| No | Reference | |||
| Yes | 0.40 (0.1–1.4) | 0.16 | ||
| HIV status | ||||
| Negative | Reference | |||
| Positive | 0.38 (0.1–1.2) | 0.09 | ||
| Resistance pattern | ||||
| INH + RIF | Reference | |||
| INH + RIF + EMB or INH + RIF + STR | 0.80 (0.3–2.1) | 0.65 | ||
| INH + RIF + EMB + STR | 2.1 (0.8–5.6) | 0.13 | ||
| Delay from sputum collection to firs post-DST visit, d | ||||
| 35–74 | Reference | |||
| 75–112 | 1.3 (04–4.6) | 0.70 | ||
| 113–155 | 1.8 (0.5–6.2) | 0.38 | ||
| >155 | 1.0 (0.3–3.8) | 0.97 |
*The patients were from 5 Thailand provinces participating in the Thailand Active TB Surveillance Network. OR, odds ratio; MDR, multidrug resistant; TB, tuberculosis; INH, isoniazid; RIF, rifampin; EMB, ethambutol; STR, streptomycin; DST, drug-susceptibility testing. †Adjusted for age as a continuous variable.