Table 3. Summary of sample analysis data from 10 horses in the 4 efficacy trials*.
| Trial no, horse ID | Prechallenge antibody titer | Euthanized, dpc | Genome detection, sample, no. dpc |
Viral infectivity control |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PM tissue | Oral swab | Rectal swab | Nasal swab | Urine | Feces | Blood | Specimen | No. died/no. total | |||||
| 1 | Horse | 1/1 | |||||||||||
| V1 | 512, 1,024 | 8 | − | − | − | − | − | − | − | ||||
| V2 |
512, 1,024 |
9 |
|
− |
− |
− |
− |
− |
− |
− |
|
|
|
| 2 | Guinea pig | 1/4 | |||||||||||
| V3 | 2,048, 4,096 | 7 | − | − | − | − | − | − | − | ||||
| V4 | 128, 256 | 8 | − | − | − | − | − | − | − | ||||
| V5 |
>4,096, >4,096 |
9 |
|
− |
− |
− |
− |
− |
− |
− |
|
|
|
| 3 | Ferret | 2/2 | |||||||||||
| V6 | >4,096, >4,096 | 7 | − | − | − | − | − | − | − | ||||
| V7 |
>4,096, >4,096 |
8 |
|
− |
− |
− |
− |
− |
− |
− |
|
|
|
| 4 | Ferret | 2/2 | |||||||||||
| V8 | 32, 32 | 7 | − | − | − | − | − | − | − | ||||
| V9 | 16, 32 | 8 | − | − | − | 2–4, 7 | − | − | − | ||||
| V10 |
16, 32 |
9 |
|
− |
− |
− |
− |
− |
− |
− |
|
|
|
| *A 100-μg dose of Hendra virus soluble G glycoprotein was used in trials 1, 3, and 4; a 50-μg dose was used in trial 2. Genome was detected by PCR. ID, identification; dpc, days after challenge; PM, postmortem. − indicates a negative result. | |||||||||||||