Table 1. Correlations between sputum assays and lung function tests.
Sputum Assay |
Bronchodilator Response |
Exercise-Induced Bronchoconstriction | ||||
---|---|---|---|---|---|---|
Max FEV1 % | AUC30 | |||||
R | p value | R | p value | R | p value | |
EOS | 0.61 | 0.02 | 0.09 | 0.54 | 0.009 | 0.84 |
ICAM | 0.67 | 0.006 | 0.69 | 0.005 | 0.62 | 0.01 |
PDGF | 0.57 | 0.02 | 0.69 | 0.005 | 0.65 | 0.008 |
RANTES | 0.64 | 0.01 | 0.66 | 0.007 | 0.61 | 0.02 |
Abbreviations: Bronchodilator Response, change in FEV1 after administration of a short-acting β2-agonist; AUC30, area under the FEV1 curve over the first 30 min after exercise (% change*min); Max FEV1 %, maximal fall in FEV1 after exercise challenge relative to baseline; EOS, sputum eosinophil counts; ICAM, halogenated intracellular adhesion molecule 1; halogenated PDGF, platelet-derived growth factor.