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. 2014 Feb 12;2014:850460. doi: 10.1155/2014/850460

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Copyright © 2014 Steven B. Zhang et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Calcium-induced hepatic mitochondrial swelling in 4 mouse strains. Hepatic mitochondria from C57BL/6, BALB/c, and C57BL/6 × BALB/c F1 hybrid mice were isolated. Calcium concentrations of 75 μM with or without 200 nM CSA were used to induce mitochondrial permeability pore opening. The response of mitochondria to calcium overload was recorded in 10-second intervals with a 540 nM spectrometer. Parental background significantly influenced the response of offspring to calcium overload. CSA was found to have a significant inhibitory effect in C57BL/6 mice and the F1 hybrids.