Table 4.
Subgroup analysis
| Cathed (Group A) 63 patients | Non-cathed (Group B) 15 patients | p-value | Good outcome (Group C) 53 patients | Poor outcome (Group D) 25 patients | p-value | |
|---|---|---|---|---|---|---|
|
Risk factors |
|
|
|
|
|
|
| Age, mean(±SD) |
61.1(14.1) |
64.9(19.5) |
0.20 |
59.4(14.9) |
67.1(14.7) |
0.01 |
| Males, no. (%) |
52(82.5) |
11(73.3) |
0.21 |
45(84.9) |
18(72.0) |
0.09 |
| Diabetes, no. (%) [1]* |
11(17.5) |
2(14.3) |
0.39 |
3(5.7) |
10(41.7) |
<0.01 |
| Hypertension, no. (%) [1] |
32(50.8) |
7(50.0) |
0.48 |
27(50.9) |
12(50.0) |
0.46 |
| Hyperlipidaemia, no. (%) [11] |
25(46.3) |
3(23.1) |
0.07 |
19(41.3) |
9(42.9) |
0.45 |
| History of IHD, no. (%) [2] |
17(27.4) |
3(21.4) |
0.33 |
15(28.8) |
5(20.8) |
0.23 |
| Serum creatinine μmol/L, median(IQR) |
102(86–115) |
125(113–161) |
<0.01 |
100(84–114) |
119(107–142) |
<0.01 |
| GFR ml/min, median(IQR) |
63(52–78) |
46(37–54) |
<0.01 |
66(55–81) |
50(42–60) |
<0.01 |
| History of smoking, no. (%) [19] |
41(80.4) |
6(75.0) |
0.37 |
34(79.1) |
13(81.3) |
0.42 |
|
Peri cardiac arrest factors |
|
|
|
|
|
|
| Time, min to first hospital, median(IQR) [16] |
52(40–61) |
70(51–80) |
<0.01 |
50(40–60) |
63(50–73) |
0.02 |
| Time, hrs to TPCH, median(IQR) |
3.9(1.0 -9.3) |
4.0(1.9–6.9) |
0.14 |
5.75(1.05–11.8) |
1.25(1–4) |
<0.01 |
| History of chest pain, no. (%) [3] |
21(33.9) |
4(30.8) |
0.42 |
16(31.4) |
9(37.5) |
0.30 |
| Time to ROSC in min, median(IQR) [11] |
15(10–25) |
22.5(15–29) |
0.36 |
13.5(10–22.2) |
20(15–35) |
0.01 |
| Treated at a peripheral hospital, no. (%) |
35(55.6) |
11(73.3) |
0.12 |
35(66.0) |
11(44.0) |
0.03 |
|
ECG factors |
|
|
|
|
|
|
| Initial rhythm VF/VT, no. (%) |
56(88.9) |
9(60.0) |
<0.01 |
47(88.7) |
18(72.0) |
0.03 |
| ST elevation, no. (%) |
30(47.6) |
2(13.3) |
<0.01 |
21(39.6) |
11(44.0) |
0.36 |
| QTc in milliseconds, mean(±SD) [2] |
453(46) |
464(51) |
0.23 |
454(48.4) |
457(43.4) |
0.42 |
|
Assessments and tests |
|
|
|
|
|
|
| GCS by paramedics, mean(±SD) [2] |
5.4(4.7) |
3.0(0) |
0.03 |
5.84(5.06) |
3.12(0.6) |
<0.01 |
| CCF in ED, no. (%) |
9(14.3) |
2(13.3) |
0.46 |
5(9.4) |
6(24.0) |
0.04 |
| First measured LVEF, mean(±SD) [6] |
37.7(17.2) |
36.7(21.6) |
0.43 |
39.2(18.2) |
33.5(16.8) |
0.11 |
| Initial serum K mmol/L, mean(±SD) |
3.9(0.7) |
4.2(0.6) |
0.06 |
3.9(0.7) |
4.0(0.7) |
0.20 |
| Initial serum Mg mmol/l, mean(±SD) [5] |
1.0(0.3) |
1.0(0.5) |
0.49 |
1.0(0.3) |
1.1(0.6) |
0.06 |
| Peak CK in IU/L, median(IQR) [9] |
1440(524–3562) |
1810(1070–4050) |
0.15 |
1440(544–3442) |
1810(613–3870) |
0.37 |
| Peak Troponin I in μmol/L, median(IQR) [5] |
20(4–71) |
9(1–35) |
0.20 |
15(5–56) |
32(1–75) |
0.42 |
|
Treatments |
|
|
|
|
|
|
| Use of inotropes, no. (%) |
27(42.9) |
8(52.3) |
0.24 |
20(37.7) |
15(60.0) |
0.03 |
| Heparin/Enoxaparin, no. (%) [1] |
59(93.7) |
14(100) |
0.34 |
51(96.2) |
22(91.7) |
0.21 |
| Aspirin, no. (%) [1] |
62(98.4) |
11(78.6) |
<0.01 |
52(98.1) |
21(87.5) |
0.03 |
| Clopidogrel, no. (%) [1] |
50(79.4) |
3(21.4) |
<0.01 |
37(69.8) |
16(66.7) |
0.39 |
| Balloon pump, no. (%) |
20(31.7) |
2(13.3) |
0.08 |
15(28.3) |
7(28.0) |
0.49 |
| ICU stay in days, median(IQR) |
4(2–6) |
4(2–5.5) |
0.36 |
4(2–6) |
4(2–4) |
0.15 |
| Coronary angiogram at any time, no. (%) |
N/A |
N/A |
N/A |
47(88.7) |
16(64.0) |
<0.01 |
|
Initially presenting to TPCH |
|
|
|
18 patients |
14 patients |
|
| Emergent coronary angiogram, no. (%) |
|
|
|
11(61.1) |
11(78.6) |
0.15 |
| Coronary angiogram at any time, no. (%) |
|
|
|
16(88.9) |
12(85.7) |
0.40 |
|
Outcomes |
|
|
|
|
|
|
| OOHCA caused by AMI, no. (%) |
45(71.4) |
6(40.0) |
0.01 |
|
|
|
| Survived to discharge, no. (%) |
47(74.6) |
6(40.0) |
<0.01 |
|
|
|
| Neurological deficit, no. (%) |
7(11.1) |
0(0.0) |
0.09 |
|
|
|
| Neurological deficit in survivors, no. (%) | 7/47(14.9) | 0/6(0.0) | 0.16 |
*[n] Number of patients for whom information was missing is represented within square brackets.
Group A = patients who had coronary angiogram (“cathed patients”).
Group B = patients who did not have coronary angiography (“non-cathed patients”).
Group C = patients who survived to discharge from hospital.
Group D = patients who died during the hospital admission.