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. 2013 Dec 13;15(2):251–265. doi: 10.1093/biostatistics/kxt055

Table 1.

Percent Bias: two-arm trial for given sampling of Inline graphic and Inline graphic; for W and Inline graphic correlation (0.8)

Time Indep.
Inline graphic Time-dep.
Multi Time-dep.
Time Indep.
Inline graphic Time-dep.
Multi Time-dep.
Estimand No Val. Some Val. High Val. Some High Some High No Some High Some High Some High
Full sampling Inline graphic and Inline graphic 1:5 Inline graphic and full Inline graphic
Inline graphic Inline graphic0.50 Inline graphic1.10 Inline graphic0.90 0.20 0.00 0.20 0.70 Inline graphic0.40 Inline graphic1.10 Inline graphic0.80 0.10 0.20 0.10 0.60
Inline graphic 0.10 Inline graphic0.40 Inline graphic0.10 Inline graphic1.50 Inline graphic0.10 Inline graphic1.40 0.10 0.10 Inline graphic0.40 Inline graphic0.10 Inline graphic1.60 0.00 Inline graphic1.70 0.10
Inline graphic Inline graphic0.50 Inline graphic1.10 Inline graphic0.90 0.40 0.30 0.40 0.40 Inline graphic0.50 Inline graphic1.10 Inline graphic0.80 0.20 Inline graphic0.00 0.80 0.60
Inline graphic Inline graphic0.40 Inline graphic0.40 Inline graphic0.10 Inline graphic1.40 0.00 0.00 0.20 0.10 Inline graphic0.40 Inline graphic0.10 Inline graphic1.50 Inline graphic0.30 Inline graphic0.40 Inline graphic0.00
No Inline graphic and full Inline graphic full Inline graphic and 1:5 Inline graphic
Inline graphic Inline graphic0.70 Inline graphic1.20 Inline graphic0.70 Inline graphic0.20 0.40 0.50 0.70 Inline graphic0.70 Inline graphic1.20 Inline graphic0.70 Inline graphic0.20 0.40 0.50 0.70
Inline graphic 1.00 Inline graphic0.50 0.10 Inline graphic1.90 Inline graphic0.30 Inline graphic1.20 Inline graphic0.10 1.00 Inline graphic0.50 0.10 Inline graphic1.90 Inline graphic0.30 Inline graphic1.20 Inline graphic0.10
Inline graphic Inline graphic0.60 Inline graphic1.10 Inline graphic0.70 0.30 0.50 0.40 0.30 Inline graphic0.60 Inline graphic1.10 Inline graphic0.70 0.30 0.50 0.40 0.30
Inline graphic 0.80 Inline graphic0.40 0.00 Inline graphic0.80 0.40 Inline graphic0.10 0.20 0.80 Inline graphic0.40 0.00 Inline graphic0.80 0.40 Inline graphic0.10 0.20
1:5 Inline graphic and Inline graphic no Inline graphic and 1:5 Inline graphic
Inline graphic Inline graphic0.70 Inline graphic1.10 Inline graphic0.70 Inline graphic0.10 0.30 0.50 0.70 Inline graphic0.50 Inline graphic1.10 Inline graphic0.60 0.00 0.10 0.30 0.60
Inline graphic 0.10 Inline graphic0.50 0.00 Inline graphic1.60 Inline graphic0.20 Inline graphic1.60 Inline graphic0.10 0.10 Inline graphic0.30 Inline graphic0.10 Inline graphic1.40 Inline graphic0.20 Inline graphic1.30 Inline graphic0.10
Inline graphic Inline graphic0.60 Inline graphic1.10 Inline graphic0.70 0.30 0.50 0.40 0.30 Inline graphic0.60 Inline graphic1.10 Inline graphic0.60 0.40 0.50 0.30 0.30
Inline graphic 0.00 Inline graphic0.50 0.00 Inline graphic1.30 0.20 Inline graphic0.40 0.10 0.00 Inline graphic0.30 Inline graphic0.10 Inline graphic1.20 0.00 Inline graphic0.30 0.10

Average bias over the 1000 simulations less than 1 Monte Carlo standard error in all cases.