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. Author manuscript; available in PMC: 2015 Mar 1.
Published in final edited form as: Br J Haematol. 2013 Dec 12;164(5):729–739. doi: 10.1111/bjh.12690

Figure 2.

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Figure 2A-D: Haemoglobinuria association with laboratory markers of haemolysis. In the UIC cohort lower haemoglobin concentration (80 vs. 90 g/l, P<0.0001), higher lactate dehydrogenase (LDH, 426 vs. 279 u/l, P<0.0001), higher aspartate transaminase (AST, 49 vs. 37 u/l, P<0.0001), and higher reticulocyte percentages (16.1% vs. 11.7%, P<0.0001) were observed in patients with haemoglobinuria. Similarly, in the Walk-PHaSST cohort, lower haemoglobin concentration (81 vs. 89 g/l, P<0.0001), higher LDH (540 vs. 428 u/l, P<0.0001), higher AST (49 vs. 42 u/l, P=0.0052), and a trend for higher reticulocyte percentage (9.6% vs. 8.5%, P=0.07) were observed in patients with haemoglobinuria. UIC = University of Illinois at Chicago; Walk-PHaSST = Walk-Treatment of Pulmonary Hypertension and Sickle Cell Disease with Sildenafil Therapy.

Figure 2E: Haemoglobinuria association with increased albuminuria. In both the UIC and Walk-PHaSST cohorts, the presence of haemoglobinuria was associated with higher levels of albuminuria (UIC: 248 vs. 20 mg/g creatinine, P<0.0001; Walk-PHaSST: 109 vs. 18 mg/g creatinine, P<0.0001). UIC = University of Illinois at Chicago; Walk-PHaSST = Walk-Treatment of Pulmonary Hypertension and Sickle Cell Disease with Sildenafil Therapy.

Figure 2F: Haemoglobinuria association with decreased GFR. In both the UIC and Walk-PHaSST cohorts, with adjustment for age the presence of haemoglobinuria was associated with decreased eGFR (UIC: 120 vs. 131 ml/min/1.73 m2, P=0.0014; Walk-PHaSST: 124 vs. 131 ml/min/1.73 m2, P=0.035). UIC = University of Illinois at Chicago; Walk-PHaSST = Walk-Treatment of Pulmonary Hypertension and Sickle Cell Disease with Sildenafil Therapy.