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. 2014 Feb 25;15:158. doi: 10.1186/1471-2164-15-158

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Copyright © 2014 Boettcher et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Inhibition of adenylate cyclases is more toxic to FH-deficient than to FH-expressing HLRCC cells. (A) Colony formation in UOK262 versus UOK262pFH after the infection with the indicated shRNA. (B) Gene expression level of adenylate cyclase genes in UOK262 and UOK262pFH. (C) Colony formation following treatment of UOK262 and UOK262pFH cells with indicated concentrations of the adenylate cyclases inhibitor MDL-12,330A. (D) Representative images of a colony survival assay of UOK262 and UOK262pFH after the treatment with 1 μM MDL-12,330A for 7 days.