Table 3.

Associations between baseline vascular factors and slope of cognitive composite decline over time, adjusted for demographics and interactions.

	Change in Attention/Speed		Change in Executive Function		Change in Language		Change in Memory		Change in Visuospatial Function
Vascular variable (see Table 1)	Estimate	P_value	Estimate	P_value	Estimate	P_value	Estimate	P_value	Estimate	P_value
Stroke	−0.01	0.16	−0.01	0.19	−0.002	0.81	0.01	0.32	0.004	0.67
Coronary heart disease	<.0001	0.89	−0.004	0.14	0.003	0.53	0.01	0.12	0.002	0.60
Cardiac arrhythmia	0.004	0.06	−0.002	0.70	0.01	0.05	0.001	0.82	−0.003	0.54
Waist: Hip Ratio (WHR)	−0.01	0.22	0.01	0.69	0.01	0.65	0.01	0.73	0.01	0.62
Heart Failure	<.0001	1.00	−0.01	0.15	−0.002	0.81	−0.01	0.36	−0.01	0.25
Cholesterol elevation	0.004	0.03	0.003	0.25	0.01	0.05	0.003	0.47	0.003	0.35
HDL cholesterol >=50 or ApoA1>=120	−0.001	0.69	−0.01	0.09	<.0001	0.95	−0.01	0.29	−0.01	0.11
LDL cholesterol >=130 or ApoB>=100	0.002	0.53	0.01	0.06	0.01	0.28	0.003	0.60	0.001	0.79
ApoB: ApoA1 ratio	0.004	0.61	0.003	0.73	−0.01	0.64	0.01	0.55	0.002	0.86
Diabetes mellitus	−0.001	0.77	−0.003	0.32	−0.01	0.31	0.001	0.82	−0.002	0.65
Diabetes and/or HbA1c >=6	0.001	0.47	<.0001	0.94	−0.002	0.66	0.01	0.08	−0.004	0.22
Hypertension and/or Systolic BP>=140	0.004	0.15	0.01	0.31	0.02	0.02	0.02	<0.01	0.01	0.08
Diastolic BP >=90	0.002	0.26	0.01	0.06	0.01	<0.01	0.01	0.10	0.002	0.51
Homocysteine>=10	−0.01	0.14	−0.02	<0.01	−0.01	0.24	0.001	0.85	−0.01	0.41
CystatinC>=1	−0.01	0.02	−0.001	0.79	<.0001	0.98	0.01	0.26	−0.01	0.19
C-Reactive Protein>=10	−0.01	0.32	−0.001	0.90	0.01	0.53	0.004	0.78	0.004	0.80
APOE*4 carrier status	−0.002	0.29	−0.01	<0.01	−0.03	<.001	−0.02	<.001	−0.01	0.03
Previous drinking	0.01	0.04	0.002	0.69	0.01	0.33	0.01	0.10	0.003	0.63
Current drinking	0.01	<.001	0.01	0.16	0.02	0.01	0.02	<0.005	0.01	0.17
Previous smoking	0.003	0.07	−0.01	0.10	−0.004	0.40	0.001	0.84	−0.003	0.32
Current smoking	0.001	0.71	−0.01	0.07	−0.02	0.02	−0.02	0.06	−0.004	0.57