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. 2014 Feb 18;106(4):824–833. doi: 10.1016/j.bpj.2013.12.041

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© 2014 The Authors

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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FKBP12.6 activates rabbit skeletal RyR1. (A) A typical single-channel experiment showing marked activation of RyR1 by 10 pM FKBP12.6. The bottom trace shows washout of FKBP12.6 from the cytosolic chamber. Po values are indicated. Dashed lines indicate open (O₁, O₂) and closed (C) channel levels, respectively. (B) Mean Po data obtained before and after addition of 10 pM, 200 nM, and 1 μM FKBP12.6 (SE; n = 5–11; ^∗∗∗p < 0.001; ^∗p < 0.05). Each concentration represents a set of independent experiments. To see this figure in color, go online.