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. 2014 Feb 18;106(4):824–833. doi: 10.1016/j.bpj.2013.12.041

Figure 1.

Figure 1

FKBP12.6 activates rabbit skeletal RyR1. (A) A typical single-channel experiment showing marked activation of RyR1 by 10 pM FKBP12.6. The bottom trace shows washout of FKBP12.6 from the cytosolic chamber. Po values are indicated. Dashed lines indicate open (O1, O2) and closed (C) channel levels, respectively. (B) Mean Po data obtained before and after addition of 10 pM, 200 nM, and 1 μM FKBP12.6 (SE; n = 5–11; ∗∗∗p < 0.001; p < 0.05). Each concentration represents a set of independent experiments. To see this figure in color, go online.