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. 2014 Feb 18;106(4):824–833. doi: 10.1016/j.bpj.2013.12.041

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© 2014 The Authors

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effects of FKBP12_{E31Q/D32N/W59F} on sheep cardiac RyR2 gating. A and B are typical examples of single-channel experiments demonstrating that neither 200 nM (A) or 1 μM (B) FKBP12_{E31Q/D32N/W59F} cause any observable effects on RyR2 activity. Dashed lines indicate open (O) and closed (C) channel levels, respectively. Po values are indicated. C and D illustrate mean Po before and after addition of 200 nM (C) and 1 μM (D) FKBP12_{E31Q/D32N/W59F}, respectively (SE; n = 5). To see this figure in color, go online.