Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Feb 18;106(4):824–833. doi: 10.1016/j.bpj.2013.12.041

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2014 The Authors

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

FKBP12_{E31Q/D32N/W59F} activates rabbit skeletal RyR1. (A) A typical experiment showing that 1 μM FKBP12_{E31Q/D32N/W59F} activates RyR1. The effects were not reversed after washout of the cis chamber (bottom trace). Open (O₁, O₂) and closed (C) channel levels are marked with dashed lines. (B) Diary plot of a typical RyR1 single-channel experiment. After washout of the cis chamber, Po did not reverse to control values. The bars indicate the incubation time with the mutant protein and subsequent washout of the protein from the cis chamber. (C) Mean Po values before and after addition of 200 nM, 500 nM, and 1 μM FKBP12_{E31Q/D32N/W59F} (SE; n = 7–11; ^∗p < 0.05). Each concentration represents a set of independent experiments. To see this figure in color, go online.